Publications 2003 - 2004

Bodetti, T., Viggers, K., Warren, K., Swan, R., Conaghty, S., Sims, C. and Timms, P. (2003) Wide range of Chlamydiales types detected in native Australian mammals. Vet. Microbiol. 96: 177-187.

Bodetti, T., Hengstberger, K., Johnston, S. and Timms, P. (2003) Evaluation of tetracycline, erythromycin, penicillin and streptomycin for decontaminating koala semen contaminated in vitro with chlamydiae. Vet. Record 153: 588-591.

Bodetti, T., Jacobson, E., Wan, C., Pospischil, A., Hafner, L., Rose, K. and Timms, P. (2003) Molecular evidence to support the expansion of the host range of Chlamydophila pneumoniae to include reptiles and amphibians. Sys. Appl. Microbiol. 25: 146–152.

Bonassi, S., Neri, M., Lando, C., Ceppi, M., Lin, Y., Chang, W.P., Holland, N., Kirsch-Volders, M., Zeiger, E., Fenech, M. and the HUMN collaborative group. (2003) Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the HUman MicroNucleus Project. Mutation Res. 540: 153-163.

Casey, J.L., Coley, A.M., Anders, R.F., Murphy, V.J., Humberstone, K.S., Thomas, A.W. and Foley, M. (2004) Antibodies to malaria peptide mimics inhibit Plasmodium falciparum Invasion of erythrocytes. Infect. Immun. 72: 1117-1125.

Cochrane, M., Pospischil, A., Walker, P., Gibbs, H. and Timms, P. (2003) The distribution of Chlamydia pneumoniae DNA in atherosclerotic carotid arteries and the significance for sampling procedures. J. Clin. Microbiol. 41: 1454–1457.

Debattista, J., Allen, J. and Timms, P (2003) Immunopathogenesis of Chlamydia trachomatis infections in women – a Review. Fertility & Sterility 79: 1273-1287.

Devereaux, L., Polkinghorne, A., Meijer, A. and Timms, P. (2003) Molecular evidence for novel chlamydial infections in the koala (Phascolarctos cinereus). Sys. Appl. Microbiol. 26: 245-253.

Fenech, M., Bonassi, S., Turner, J., et al. (2003) Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project. Mutation Res. 534: 45-64.

Fenech, M., Chang, W.P., Kirsch-Volders, M., Holland, N., Bonassi, S. and Zeiger E. (2003) HUMN Project: Detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures. Mutation Res. 534: 65-75.

Fung, K.Y.C., Glode, L.M., Green, S. and Duncan, M.W. (2004) A comprehensive characterization of the peptide and protein constituents of human seminal fluid. The Prostate 9999: 1-11.

Greenrod, W., and Fenech, M. (2003) The principal phenolic and alcoholic components of wine protect human lymphocytes against hydrogen peroxide- and ionizing radiation-induced DNA damage in vitro. Mutagenesis 18: 119-26.

Hodge, G., Hodge, S., Haslam, R., McPhee, A., Sepulveda, H., Morgan, E., Nicholson, I. and Zola, H. (2004) Rapid simultaneous measurement of multiple cytokines using 100uL sample volumes - Association with neonatal sepsis. Clin. Exp. Immunol. 137: 402-407.

Hogan, R., Mathews, S., Kutlin, A., Hammerschlag, M. and Timms, P. (2003) Differential expression of genes encoding membrane proteins between acute and continuous Chlamydia pneumoniae infections. Microbial Pathogen. 34: 11-16.

Hogan, R., Mathews, S., Mukhopadhyay, S., Summersgill, J. and Timms, P. (2004) Chlamydial persistence: beyond the biphasic paradigm. Infect. Immun. 72: 1843-1855.

Hudson, P.J. and Souriau, C. (2003) Engineered antibodies. Nature Med. 9: 129-134.

Huygens, F., Stephens, A.J., Nimmo, G. and Giffard. P.M. (2004) mecA locus diversity in MRSA isolates in Brisbane, Australia and the development of a novel diagnostic test for the Western Samoan Phage Pattern clone. J. Clin. Microbiol. 42: 1947-1955.

Keizer, D.W., Miles, L.A., Li, F., Nair, M., Anders, R.F., Coley, A.M., Foley, M. and Norton, R.S. (2003) Structures of phage-display peptides that bind to the malarial surface protein, Apical Membrane Antigen 1, and block erythrocyte invasion. Biochem. 42: 9915-9923.

Kimura, M., Umegaki, K., Higuchi, M., Thomas, P. and Fenech, M. (2004) MTHFR C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes. J. Nutr. 134: 48-56.

Mavrangelos, C., Swart, B., Nobbs, S., Nicholson, I.C., Macardle, P.J. and Zola, H. (2004) Detection of low-abundance membrane markers by immunofluorescence - A comparison of alternative high-sensitivity methods and reagents. J. Immunol. Meth. 289: 167-178.

Nuttall, S.D., Humberstone, K.S., Krishnan, U.V., Carmichael, J.A., Doughty, L., Hattarki, M., Coley, A.M., Casey, J.L., Anders, R.F., Foley, M., Irving, R.A. and Hudson, P.J. (2004) Selection and affinity maturation of IgNAR variable domain targeting Plasmodium falciparum AMA1. Proteins 55: 187-197.

Nuttall, S.D., Krishnan, U.V., Doughty, L., Pearson, K., Ryan, M.T., Hoogenraad, N.J., Hattarki, M., Carmichael, J.A., Irving, R.A. and Hudson, P.J. (2003) Isolation and characterization of an IgNAR variable domain specific for the human mitochondrial translocase receptor Tom70. Eur. J. Biochem. 270: 3543-3554.

Power, B.E., Doughty, L., Shapira, D.R., Burns, J.E., Bayly, A.M., Caine, J.M., Liu, Z., Scott, A.M., Hudson, P.J. and Kortt, A.A. (2003) Non-covalent scFv multimers of tumour-targeting anti-Lewisy hu3S193 humanised antibody. Protein Sci. 12: 734-747.

Power, B. and Hudson, P. (2003) Keystone Symposia: Antibody-Based Therapeutics for Cancer. Exp. Opin. Biol. Ther. 3: 385-389.

Robertson, G.A., Thiruvenkataswamy, V., Shilling, H., Price, E.P., Huygens, F., Henskens, F.A. and Giffard, P.M. (2004) Identification and interrogation of highly informative single nucleotide polymorphism sets defined by bacterial multilocus sequence typing databases. J. Med. Microbiol. 53: 35-45.

Schmidt, A., Gale, K., Ellis, M. and Giffard P. (2004). Sequence variation at a microsatellite locus (XGWM261) in hexaploid wheat (Triticum aestivum). Euphytica 139: 239-246.

Tang, S-L., Nuttall, S.D. and Dyall-Smith, M. L. (2004) Haloviruses HF1 and HF2: Evidence for a recent and large recombination event. J. Bacteriol. 186: 2810-2817.

Thomas, P., Umegaki, U. and Fenech, M. (2003) Nucleoplasmic bridges are a sensitive measure of chromosome rearrangement in the cytokinesis-block micronucleus assay. Mutagen. 18: 187-94.

Voisey, J., Carroll, L. and van Daal, A. (2003) Melanocortins and their receptors and antagonists. Curr. Drug Targets 4: 586-597.

Voisey J., Kelly, G. and van Daal, A. (2003) Agouti Signal Protein regulation in human melanoma cells. Pigment Cell Res. 16: 65-71.

Wang, X. and Fenech, M. (2003) A comparison of folic acid and 5-methyl tetrahydrofolate for prevention of DNA damage and cell death in human lymphocytes in vitro. Mutagen. 18: 81-86.

Wilson, D., Timms, P. and McElwain, S. (2003) A mathematical model for the investigation of the Th1 immune response to Chlamydia trachomatis. Mathematical Biosciences 182: 27–44.

Zola, H. and Swart, B. (2003) Human Leucocyte Differentiation Antigens. Trends Immunol. 24: 353-354.

Carroll, L., Voisey, J. and van Daal, A. (2004) Mouse models of obesity. Clinics in Dermatology (in press).

Carroll, L., Voisey, J. and van Daal, A (2004) Gene polymorphisms and their effects in the Melanocortin system. Peptide (in press).

Coombs, G,W., Nimmo, G.R., Bell, J.M., Huygens, F., O'Brien, F., Malkowski, M., Pearson, J., Stephens, A.J., Giffard, P.M. and the Australian Group for Antimicrobial Resistance (AGAR). (2004) Community methicillin-resistant Staphylococcus aureus in Australia: Genetic diversity in strains causing outpatient infections. J. Clin. Microbiol. (in press).

Dhillon, V.S., Thomas, P. and Fenech, M. (2004) A comparison of DNA damage and repair following radiation challenge in buccal cells and lymphocytes using single cell gel electrophoresis. Int. J. Radiation Biol. (in press).

Debattista, J., Gazzard, C., Wood, R., Allan, J.A., Allan, J.M., Scarman, A., Timms, P. and Knox, C. (2004) Microbiological analysis of samples from women undergoing falloposcopic investigations for infertility. Hum. Reprod. (in press).

Graf, J., Hodgson, R. and van Daal, A. (2004) Single Nucleotide Polymorphisms in the MATP Gene are associated with normal human pigmentation variation. Human Mutation (in press).

Hammond, D, Huygens, F., Nimmo, G., Schooneveldt, J. and Giffard, P.M. (2004) BlaSHV genes in Klebsiella pneumoniae: Different allele distributions are associated with different promoters within individual isolates. Antimicrob. Agents Chemother. (in press).

Li, F., Dluzewski, A., Coley, A., Casey, J., Tilley, L., Anders, R.F. and Foley, M. (2004) Phage display peptides bind to the malarial protein Apical Membrane Antigen-1 and inhibit the invasion of merozoites into host erythrocytes. J. Biol. Chem. (in press).

Mashiyama, S.T., Coutemanche, C., Elson-Schwab, I., Crott, J., Lee, B.L., Ong, C.N., Fenech, M. and Ames, B.N. (2004) Uracil in DNA, determined by an improved assay, is increased when deoxynucleotides are added to folate-deficient cultured human lymphocytes. Analyt. Biochem. (in press).

Streltsov, V.A., Varghese, J.N., Carmichael, J.A., Irving, R.A., Hudson, P.J. and Nuttall, S.D. (2004) Structural evidence for evolution of shark Ig New Antigen Receptor variable domain antibodies from a cell-surface receptor. Proc. Natl. Acad. Sci. USA (in press).

Sugisawa, A., Kimura, M., Fenech, M. and Umegaki, K. (2004). Anti-genotoxic effects of tea catechins against reactive oxygen species in human lymphoblastoid cells. Mutation Res. (in press).

Wang, X., Thomas, P., Xue, J. and Fenech, M. (2004) Folate deficiency induces aneuploidy in human lymphocytes in vitro – evidence using cytokinesis-blocked cells and probes specific for chromosome 17 and 21. Mutation Res. (in press).

Book chapters published

Fenech M. (2003) Liver or broccoli? Food's lasting effect on genome methylation. In: The Epigenome. Molecular Hide and Seek. (S. Beck & S. Olek, eds). Wiley-VCH GmbH & Co KG Grunstadt pp. 119-138.

Fenech, M. (2003) Nutritional treatment of genome instability: a paradigm shift in disease prevention and in the setting of recommended dietary allowances. Nutr. Res. Reviews Vol 16, pp109-122.

Fenech M. (2004) The in vitro micronucleus technique. In: Methods in Molecular Medicine – Chemosensitivity. (R. Blumenthal, ed). Humana Press (in press).

Power, B.E., Kortt, A.A. and Hudson, P.J. (2003) Generation of recombinant multimeric antibody fragments for tumor diagnosis and therapy. In: Recombinant Antibodies for Cancer Therapy in the series “Methods in Molecular Biology”. (M. Welschof and J. Krauss, eds.) Humana Press. Vol 207, pp 335-350.

Wang, D. H., Lee, N.K. and Dillon, T.S. (2003) Extraction and optimization of Fuzzy Protein Sequence classification rules using GRBF neural networks. Neural Info. Process. - Letters & Reviews 1: 53-59.

Zola, H. (2003) Monoclonal antibodies. In: Nature Encycl. Life Sci.. (in press).

Zola, H. (2004) Monoclonal antibodies: Therapeutic uses. In: Nature Encycl. Life Sci. (in press).

Zola, H. and Roberts-Thompson, P. (2004) Monoclonal antibodies: Diagnostic uses. In: Nature Encycl. Life Sci. (in press).

Conference proceedings published

Fenech M. (2003) Genomic stability: A new paradigm for recommended dietary allowances (RDAs). In “Modern aspects of nutrition – Present knowledge and future. Perspectives” Proc. 17th Int. Cong. Nutrition, August 27-31 (2001), Vienna, Austria. (I. Elmadfa, E. Anklam and J.S. Konig, eds). Forum of Nutrition, vol. 56 pp. 97-100. Karger Publ. (Basle, Switzerland)

Kirsch-Volders, M., Sofuni, T., Aardema, M., Albertini, S., Eastmond, D., Fenech, M., Ishidate, M. Jr., Kirchner, S., Lorge, E., Morita, T., Norppa, H., Surralles, Vanhauwaert, A. and Wakata, A. (2003) Report from the in vitro micronucleus assay working group. Published in Mutation Research vol 540 pp. 153-63.

Shapira, D.R., Power, B.E., Cody, S., Kiki, T., Lee, F.T., Scott, A.M. and Hudson, P.J. (2004) In vitro binding and internalization of engineered single chain Fv antibody fragments of anti-lewis Y humanized monoclonal antibody (HU3S193). Presentation at ISAC Int. Congress, Montpellier, France. May 21-27. Published in Cytometry vol 59a p138.

Wang, D.H., Lee, N.K, and Dillon, T.S. (2003) Data mining for building neural protein sequence classification systems with improved performance. Proc Int. Joint Conf. Neural Networks. 20-24 July. Portland, Oregon, USA.

Conference abstracts and posters

Bayly, A. (2003) The non-covalent association of single-chain antibodies to form trimers and tetramers for cancer targeting. COMBIO 2003, Melbourne, Australia. Sep 28 - Oct 2.

Casey, J.L., Coley, A.M., Parisi, K., Thomas, A., Anders, R.F. and Foley, M. (2003) Antibodies to peptide mimics block malaria invasion of red blood cells. Australian Society for Parasitology. Conference, Darwin, Australia. Jul 7-11.

Casey, J.L., Coley, A.M., Parisi, K., Thomas, A., Anders, R.F. and Foley, M. (2004). Antibodies to peptide mimics inhibit Plasmodium falciparum invasion of erthyrocytes. Molecular Approaches to Malaria Conference, Lorne, Australia. Feb 1-5.

Coley A.M., Parisi, K., Casey, J.L., Murphy, V.J., Anders, R.F. and Foley, M. (2003). The effect of single amino acid substitutions on antigenicity of vaccine candidate proteins using phage display. Australian Society for Parasitology. Conference, Darwin, Australia. Jul 7-11.

Coley A.M., Parisi, K., Casey J.L., Murphy V.J., Anders R.F. and Foley M. (2003). The effect of single amino acid substitutions on antigenicity of vaccine candidate proteins using phage display. Molecular Approaches to Malaria Conference, Lorne, Australia. Feb 1-5.

Dunning, C.J.R., Ohtake, A., Hoogenraad, N.J., Thorburn, D.R. and Ryan, M.T. (2003) Mitochondrial Respiratory Complex I : Bio-genesis and analysis of assembly defects. COMBIO 2003, Melbourne, Australia. Sep 28 - Oct 2.

Dunning, C.J.R., Ohtake, A., Hoogenraad, N.J., Thorburn, D.R. and Ryan, M.T. (2004) Mitochondrial Respiratory Complex I: Biogenesis and analysis of assembly defects. 29th Annual Lorne Conference on Protein Structure and Function, Lorne, Australia. Feb 8-12.

Furness, D. (2004). Evaluation of the use of the Cytokinesis Block Micronucleus Assay to determine inter-individual variation in spontaneous and folate deficient-induced genome damage in humans. ASMR State Conference, South Australia. Adelaide, Australia. Jun 4.

Griffith, K. (2003) Identification of proteinaceous binders with high affinity for therapeutic targets. COMBIO 2003, Melbourne, Australia. Sep 28 - Oct 2.

Griffith, K. (2004) Identification of proteinaceous binders with high affinity for therapeutic targets. 29th Annual Lorne Conference on Protein Structure and Function, Lorne, Australia. Feb 8–12.

Griffith, K. (2004) Identification of proteinaceous binders with high affinity for therapeutic targets. AntibOZ 2, Heron Island, Australia. Mar 18-23.

Hodge, G., Hodge, S., Haslam, R., McPhee, A., Sepulveda, H., Morgan, E., Nicholson, I. and Zola, H. (2004) Rapid detection of neonatal sepsis by simultaneous measurement of multiple cytokines using 100uL sample volumes. XXII Int. Conference of the International Society of Analytical Cytometry, Montpellier, France. May 22-27.

Hoogenraad, N. (2003) Docking mechanism for chaperone delivery of preproteins to the surface of mitochondria. Int. Nodes for Protein Engineering Centres, Bromont, Canada. Jul 25-28.

Hoogenraad, N. (2003) A mitochondrial-specific unfolded protein response in mammalian cells. Hunter Cellular Biology Meeting, Pokalbin, Australia. Apr 9-11.

Hoogenraad, N (2003) A mitochondrial-specific stress response. Cellular Quality Control Meeting, Cologne, Germany. Mar 26-28.

Hudson. P. (2003) Novel binding molecules; High affinity reagents for clinical applications. MicroNZ 2003, Auckland, New Zealand. Sep 28 - Oct 2.

Humberstone, K.S., Coley, A.M., Casey, J.L., Nuttall, S.D., Masciantonio, R., McMahon, A., Li, F., Murphy, V.J., Schloegel, J.L., Anders, R.F. and Foley, M. (2004). Invasion inhibitory molecules bind a similar site on the malarial protein Apical Membrane Antigen 1. Molecular Approaches to Malaria Conference, Lorne, Australia. Feb 1-5.

Humberstone, K.S., Coley, A.M., Casey, J.L., Masciantonio, R., McMahon, A., Li, F., Murphy, V.J., Schloegel, J.L., Anders, R.F. and Foley, M. (2003) Identifying functional regions of a malarial antigen using peptides selected from phage-displayed random peptide libraries. 5th Australian Peptide Conference, Daydream Island, Australia. Oct 5-10.

Humberstone, K.S., Coley, A.M., Casey, J.L., Masciantonio, R., McMahon, A., Li, F., Murphy, V.J., Schloegel, J.L., Anders, R.F. and Foley, M. (2004). Invasion inhibitory molecules bind a similar site on the malarial protein Apical Membrane Antigen 1. 29th Protein Structure and Function Conference, Lorne, Australia. Feb 7-12.

Irving, R.A. and Hudson, P.J. (2003) Microarrays and nanochips - From proteome discovery to DNA diagnosis. DNA Analysis for Human Health in the post genomic era: APEC wide foresight study, Bangkok, Thailand. Aug 26-28.

Johnston, A. J., Hoogenraad, N.J. and Ryan, M.T. (2003) Targeting of Tom7 and its assembly into the Tom Complex. COMBIO 2003, Melbourne, Australia. Sep 28 - Oct 2.

Johnston, A.J., Hoogenraad, N.J. and Ryan, M.T. (2004) Dissection of the targeting and assembly signals of Tom7, a component of the mitochondrial protein import machinery. 29th Annual Lorne Conference on Protein Structure and Function, Lorne, Australia. Feb 8-12.

Kimura, M., Umegaki, K., Higuchi, M., Thomas, P. and Fenech, M. (2003) MTHFR C677T polymorphism, folic acid and riboflavin are important determinants of genome stability. ICMAA VIII Anti-Mutagenesis and Anti-Carcinogenesis Meeting, Pisa, Italy. Oct 4-8.

Muharam, I., Hodgson, R., Westacott, L., White, S. and van Daal, A. (2004). Forensic applications of whole genome amplification. 7th Int. Conf. on Ancient DNA and Associated Biomolecules, Brisbane, Australia. Jul 12-16.

Muharam, I., Hodgson, R., and van Daal, A. (2004). 2,000,000 PCR reactions generated by whole genome amplification of limited forensic samples. 7th Int. Conf. on Ancient DNA and Associated Biomolecules, Brisbane, Australia. July 12-16.
Mustafa, H., Rauth, S., Abregu, M., Wark, K. and Irving, R. (2004). Expression and surface display of a green fluorescent protein in mammalian cells. 29th Annual Lorne Conference on Protein Structure and Function, Lorne, Australia. Feb 8-12.

Nathanielsz, A., Nuttall, S.D., Irving, R.A and Hudson, P.J. (2003) Selection and molecular evolution of IgNAR’s against AMA-1. IBC’s 14th Annual Antibody Engineering Conference, San Diego, USA. Nov 30 - Dec 3.

Nutttall, S. (2003) Single domain binding reagents from shark antibodies. COMBIO 2003, Melbourne, Australia. Sep 28 - Oct 2.

Peisley, A. (2003) Definition of the MMP-2/collagen binding interface and inhibitor design. COMBIO 2003, Melbourne, Australia. Sep 28 - Oct 2.

Pow, A., Wark, K., Atwell, J., Mustafa, H. and Irving, R. (2004) A fluorescent display system for the in vivo detection of diagnostic binding reactions’. 29th Lorne Conference on Protein Structure and Function, Lorne, Australia. Feb 8-12.

Schloegel J.L., Coley A.M., Casey J.L., Murphy V.J., Anders R.F. and Foley M. (2004). Investigating the immunoreactive regions of AMA-1, a vaccine candidate. Molecular Approaches to Malaria Conference, Lorne, Australia. Feb 1-5.

Shapira, D. (2003) Problems associated with measuring genotoxicity by flow cytometry. 26th Annual Conference of the AFCG. Mooloolaba, Australia. Oct 13-15.

Simmons, D.P., Isol, D., Nuttall, S.D., Irving, R.A., Hoogenraad, N.J. and Hudson, P.J. (2003) High affinity reagents from antibody/protein libraries for detection and diagnostics of potential biological warfare agents. COMBIO 2003, Melbourne, Australia. Sep 18 - Oct 2.

Stephens, AJ., Huygens, F. and Giffard, P. (2003) PCR typing of MRSA by mapping the mecA downstream region. MicroNZ 2003, Auckland, New Zealand. Sep 28 - Oct 2.

Swart B. and Zola, H. (2004) The 8th International Workshop and Conference on Human Leucocyte Differentiation Antigens (HLDA8): 2000-2004. XXII Int. Conf., Int. Soc. Analyt. Cytometry, Montpellier, France. May 22-27.

Wang, D.H., Lee, N.K, and Dillon, T.S. (2003) Data mining for building neural protein sequence classification systems with improved performance. Proc Int Joint Conf on Neural Networks, Portland, Oregon, USA. Jul 20-24.

Ward, L.A., Herd, S.M. and Hoogenraad, N.J. (2003) Function and substrates of the mammalian chaperone system. COMBIO 2003, Melbourne, Australia. Sep 28 - Oct 2.

Ward, L.A., Ryan, M.T., Herd, S.M. and Hoogenraad, N.J. (2004) Mammalian CPN60 : Function and malfunction in the mitochondrial matrix. 29th Annual Lorne Conference on Protein Structure and Function, Lorne, Australia. Feb 8-12.

Weston, R., Casey, J.L., Alderton, M. and Foley, M. (2003). Screening a peptide library displayed on phage to identify reagents that bind to lethal factor from Bacillus anthracis. 5th Australian Peptide Conference, Daydream Island, Australia. Oct 5-10.

Weston, R., Casey, J.L., Alderton, M. and Foley, M. (2003). Screening a peptide library displayed on phage to identify reagents that bind to lethal factor from Bacillus anthracis. 29th Protein Structure and Function Conference, Lorne, Australia. Feb 7-12.